Petr Zuska graduated from the Dance Department of the Academy of Performing Arts, Prague, in 1994. Subsequently he appeared with the Charles University Dance Company and than he became a member of Prague's Theatre Na Zábradlí Pantomime group. The crucial phase in his career was the engagement in the Prague Chamber Ballet (as a member from 1989 to 1992 then since 1994 as a guest artist). Here he encountered the choreographies of Pave Smok as well as works of Jirí Kilián, Robert North, Gerhard Bohner, and others. In years 1992 to 1998 he gained experience in the National Theater Ballet in Prague, where he performed many roles, such as; The Dreamy Double in Der kleine Herr Friedemann (Little Mr. Friedemann)1993, Norman Bates in Psycho (for which he won a Czech Literary Fund Prize and a Thalia Award in 1993), Tchaikovsky in the ballet of the same name, the role of the Dancer Jerry in Some Like It ... (1994), Yesenin in Isadora Duncan (1998) - The Story of a Famous Dancer, Don José in Carmen (1997 Thalia Award), Tybalt in Romeo and Juliet (1997), and solo parts in Kylián's Field Mass and Return to a Strange Land.

Since 1990 he has choreographed many productions for theaters, dance groups, Czech Television, The Prague Conservatory, Prague Chamber Ballet, Laterna Magica and Prague National Theater. Some of his choreographies to this date are: Out of the Depths, Adagietto (1994 Czech Literary Fund Prize), Small Gallows - other 1994 Czech Literary Fund Prize), Seul (inspired by the songs of Jacques Brel - 1995), the duet In the Mist to music by Leos Janácek (1996, prize for the best choreography), the full-length ballet Komboloi (1997) to music by Zbynek Mateju, and Sonata (1999) again to the music by Leos Janácek.

In 1998 Petr Zuska joined the Munich Ballet Theater directed by Philip Taylor. Here he danced solos in choreographies by Philip Taylor, Jirí Kylián, and Rui Horta. In 1999 he joined the Ballett Theater in Augsburg where he worked with the young German choreographer Jochen Heckmann, and besides dancing he devoted himself to choreography as well. He was awarded the Prix Dom Perignon in the category for young choreographers for his Triple Self to the Piano Trio in E Minor by Dimitrij Shostakovich. This choreography was included in the repertoire of the Hamburg Ballet.

In 2000 he became a regular soloist in Les Grands Ballets Canadiens in Montreal. There he performed the role of Don José in Carmen by the progressive Dutch choreographer Dida Veldman. He danced to works of world-renowned choreographers such as Jirí Kylián, Nacho Duato, and Ohad Naharin and took part in gala performances in Canada and Germany both as a dancer and a choreogrpaher. At this time he created the ballet Ways (2001) music by Arvo Pärt, staged at the Semper Opera in Dresden. In 2002 he choreographed Le bras de mer to music of Yann Tiersen, which premiered at Laterna magica in Prague, followed by choreography Maria's Dream for the Prague Chamber Ballet and Clear Invisible a ballet for the Latvian National Opera in Riga.

In September 2002 Petr Zuska became the Artistic Director of the Ballet of the National Theater Prague. Beside his choreographic work he performs as a soloist in the company's contemporary repertoire. For this company he choreographed Among the Mountains (2002), a composition of Czech and Moravian folk songs arranged and stylized by the popular Czech band Cechomor and Ways 03 (music by Arvo Pärt). In February 2005 Petr Zuska directed the performance Ballet Mania and his latest work is a full-length dramatic ballet Ibbur, or Prague Mystery (2005) to music by Zbynek Mateju. The Ballet of the National Theatre's repertoire includes the earlier choreographies of Petr Zuska -Les Bras de Mer and Maria's Dream.

In 2004 he created the choreography called The Last Photo...? for the Ballet Augsburg, which was inspired by the one act play by Samuel Beckett The Last Tape. Next he created a ballet entitled D.M.J. 1953-77 for The National Theatre Ballet in Brno. In February 2005 Petr Zuska directed Ballet Mania for the Ballet of the National Theatre Prague. This is a composed evening, showing the history of ballet and it includes also his works as a choreographer. In March 2005 Petr Zuska accepted the invitation by the principal dancer of the Mariinski Theater Diana Vishneva to perform with her his choreography Les Bras de Mer as a part of her Benefit performance. This choreography stays on the repertoire of Ballet Kirov. Presently is the ballet Les Bras de Mer on the repertoire of the Royal Danish Theater Ballet. A few months later he choreographed for the Ballet of the National Theatre Prague the full-length dancing drama Ibbur, or A Prague Mystery inspired by Gustav Meyrink's famous novel Golem.

In 2006, marking the anniversary of Mozart's birth, Petr Zuska created the ballet Requiem again, for the Ballet of the National Theatre Prague.

The artistic director of the Dusseldorf Ballet Youri Vamos, invited Petr Zuska to make an unconventional choreography for the company, which premiered in May 2006. The piece, A Little Extreme, is danced to rap and hip-hop music.

In May 2007, Petr Zuska finished the full-length dance theatre piece based on chansons by Jacques Brel, Vladimir Vysockij and Karel Kryl named Solo for Three. He choreographed and directed this for the Ballet of the National Theatre in Prague.